Additional file 1 of Unraveling the causality between gastroesophageal reflux disease and increased cancer risk: evidence from the UK Biobank and GWAS consortia

Additional file 1: Table S1. Overview of data. Table S2. All-selected SNPs in the study. Table S3. Mendelian randomization analysis of GERD association with pan-cancer risk. Table S4. 63 unique potential confounding SNPs. Table S5. Sensitivity analysis for GERD and cancer. Table S6. Outlier analysis and correction of SNPs. Table S7. Reverse MR analysis of cancer on GERD. Table S8. Comparison of effects before and after adjusting variables. Table S9. Mendelian randomization analysis of the major depression, BMI, and smoking initiation association with pan-cancer risk. Table S10. Results from a two-step Mendelian randomization mediation analysis.

补充文件1：表S1。数据概况。表S2：本研究纳入的全部筛选单核苷酸多态性（Single Nucleotide Polymorphisms, SNPs）。表S3：胃食管反流病（Gastroesophageal Reflux Disease, GERD）与泛癌风险关联的孟德尔随机化（Mendelian Randomization, MR）分析结果。表S4：63个独特的潜在混杂单核苷酸多态性。表S5：胃食管反流病与癌症关联的敏感性分析结果。表S6：单核苷酸多态性的异常值分析与校正。表S7：癌症对胃食管反流病的反向孟德尔随机化分析结果。表S8：变量校正前后的效应对比结果。表S9：重度抑郁症（Major Depression, MD）、体质量指数（Body Mass Index, BMI）及吸烟起始与泛癌风险关联的孟德尔随机化分析结果。表S10：两步法孟德尔随机化中介分析的结果。