Additional file 1: of Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)

GRADE Table - First area - PK variability provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the first area of the guidelines: “Pharmacokinetic variability of beta-lactam antibiotics”. GRADE Table - Second area – PK-PD provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the second area of the guidelines: “Pharmacokinetic-Pharmacodynamic relationship of beta-lactam antibiotics”. GRADE Table - Third area – Administration of beta-lactams provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the third area of the guidelines: “Administration of beta-lactam antibiotics”. GRADE Table - Fourth area – TDM provides the GRADE Table summarizing the methods and the results of the studies taken into consideration to formulate the recommendations of the fourth area of the guidelines: “Therapeutic Drug Monitoring of beta-lactam antibiotics”. Flow-charts of study seletion provides a flow chart of the selection of the relevant studies among all the studies identified by the literature search for each of the four areas of the guidelines. Supplementary method file provides the keywords used for the bibliographic search for each of the four areas of the guidelines. (ZIP 134 kb)

GRADE（Grading of Recommendations Assessment, Development and Evaluation）表——第一主题：β-内酰胺类抗生素（beta-lactam antibiotics）的药代动力学（Pharmacokinetic）变异性：本GRADE表汇总了为制定本指南该主题相关推荐意见所纳入的各项研究的方法与结果。GRADE表——第二主题：β-内酰胺类抗生素的药代动力学-药效动力学（Pharmacokinetic-Pharmacodynamic，简称PK-PD）关系：本GRADE表汇总了为制定本指南该主题相关推荐意见所纳入的各项研究的方法与结果。GRADE表——第三主题：β-内酰胺类抗生素的临床给药：本GRADE表汇总了为制定本指南该主题相关推荐意见所纳入的各项研究的方法与结果。GRADE表——第四主题：β-内酰胺类抗生素的治疗药物监测（Therapeutic Drug Monitoring，简称TDM）：本GRADE表汇总了为制定本指南该主题相关推荐意见所纳入的各项研究的方法与结果。研究筛选流程图：针对本指南上述四大主题，分别提供了从文献检索识别的全部研究中筛选相关研究的流程示意图。补充方法文件：收录了本指南四大主题文献检索所用的检索关键词（压缩包大小134KB）。