miRNAs associated with plaque density score.

Neuropathological examination disclosed total plaque-density score ranging from 1–15 for each subject. Scores were divided into three groups corresponding to low plaque-density score (1–5), moderate plaque-density score (6–10) and high plaque-density score (11–15). Ultimately, plaque density subgroups consisted of stage 1 (n = 58), stage 2 (n = 41) and stage 3 (n = 85) subjects for CSF and stage 1 (n = 55), stage 2 (n = 35) and stage 3 (n = 74) for SER. The ordinal regression method was used to model the relationship between the ordinal outcome variable, plaque density score, and normalized miRNA counts as explanatory variable. Delta AIC quantifies the information loss associated with using each model relative to the best approximating model. We report miRNAs with the lowest AIC value and . p-Value* is unadjusted.