Mus musculus Transcriptome or Gene expression

Protein kinase C delta (PKC-d) is a member of the PKC protein family that plays a critical role in the regulation of various cellular processes including cell proliferation, cell death, and tumor promotion. In recent years it was reported that PKC-d also functions as an important regulator in bone metabolism. However, the precise involvement of PKC-d in the regulation of osteoclast biology and bone homeostasis remains elusive. We generated an osteoclast specific PKC-d conditional knockout (cKO) mouse strain to investigate the function of PKC-d in osteoclast biology.