Gene expression profiling of MYC inducible murine tumor models (cell lines) [microarray]

The transcription factor, c-MYC, is a proto-oncogene that is activated in many types of cancer. To study how MYC promotes and maintains the neoplastic phenotype, we use tetracycline-regulated systems in transgenic mice whereby we can conditionally activate MYC. We profile the changes in gene expression when MYC is activated versus inactivated in order to identify a gene signature that is associated with the ability of MYC to promote tumorigenesis. Total RNA was obtained from cell lines derived from the tumors of transgenic mice with tetracycline-regulated MYC expression.