Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) table for Prostate, v1.1

Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) tables (https://humanatlas.io/asctb-tables) aim to capture<br>anatomical human body parts, the typology of cells, and biomarkers used to identify cell types. The tables are<br>authored and reviewed by an international team of experts. The Prostate ASCT+B table represents terms related to the<br>adult human prostate. These include both macroscopic and microscopic anatomical structures, major cell types, and<br>protein biomarkers specific for each cell type listed. This table was generated based on published histopathologic<br>nomenclature, as well as published literature on cell-type specific biomarkers. Most of the markers listed are<br>observed in more than one study or orthogonally validated. Note that these are predicted markers and a single marker<br>to annotate a cell type is not likely sufficient or specific. Where more refined cell types are not available in the<br>ontologies, the closest general term is used. For example, there are likely multiple types of prostate stromal cells;<br>however, further characterization is needed to distinguish between these cell types. Where cells of similar type occur<br>in different locations, the closest and highest level of resolution available is used. For example, basal epithelial<br>cells and luminal epithelial cells occur in multiple different contexts within the prostate, including the peripheral<br>zone, central zone, and transition zone.<br><br>**Bibliography:**<br><br>* Madissoon, E., A. Wilbrey-Clark, R. J. Miragaia, K. Saeb-Parsy, K. T. Mahbubani, N. Georgakopoulos, P. Harding, et al. 2019. “scRNA-Seq Assessment of the Human Lung, Spleen, and Esophagus Tissue Stability after Cold Preservation.” *Genome Biology* 21 (1): 1. https://doi.org/10.1186/s13059-019-1906-x.<br>* Steiniger, B. S., V. Wilhelmi, M. Berthold, M. Guthe, and O. Lobachev. 2018. “Locating Human Splenic Capillary Sheaths in Virtual Reality.” *Scientific Reports* 8 (1): 15720. https://doi.org/10.1038/s41598-018-34105-3.<br>* Steiniger, Birte S. 2015. “Human Spleen Microanatomy: Why Mice Do Not Suffice.” *Immunology* 145 (3): 334–46. https://doi.org/10.1111/imm.12469.<br>* Steiniger, Birte, Vitus Stachniss, Hans Schwarzbach, and Peter J. Barth. 2007. “Phenotypic Differences between Red Pulp Capillary and Sinusoidal Endothelia Help Localizing the Open Splenic Circulation in Humans.” *Histochemistry and Cell Biology* 128 (5): 391–98. https://doi.org/10.1007/s00418-007-0320-8.