Route for the Generation of Trifluoromethyl-Substituted Pyrrplo[3,2‑c]quinolines

Generation of trifluoromethyl-substituted pyrrolo­[3,2-c]­quinolines via a copper­(II)-catalyzed tandem reaction of N-(σ-iodoaryl)­alkynylimines with 2-isocyanoacetates is reported. The process involves a [3 + 2] cycloaddition and intramolecular C–C bond coupling, leading to the fluorine-containing N-heterocycles under mild conditions with high efficiency.