Genetic and epigenetic profiles of elderly AML. Homo sapiens

Since characterization of molecular alterations in elderly acute myeloid leukemia (AML) patients using comprehensive studies are lacking, we investigated genetic and epigenetic alterations to unravel the specific background of this unfavorable disease. We studied AML patients by sequencing 555 genes on an Illumina HiSeq2000 platform and investigated DNA methylation profiles using the Illumina 450K array. Overall design: Bisulfit converted genomic DNA samples extracted from bone marrow of elderly AML (n=79) were hybridized onto an Illumina Infinium HumanMethylation450 Beadchip.