Associations of validated CHD loci with incident coronary heart disease in African Americans.

Abbreviations: LD, linkage disequilibrium; SNP, single nucleotide polymorphism; AA, African Americans from PAGE studies; NA, not available. Only SNPs with minor allele frequency>0.01 that passed quality control are included. Linkage disequilibrium in African Americans was calculated in the ARIC study and allele frequencies from the ARIC and WHI genotyped data. Thresholds for significant associations for SNPs with LD r2<0.3 with published SNP were based on the number of SNPs in each region.
*proxy of rs1760994,
†proxy of rs4977574. Between-study heterogeneity was not significant (p<0.05) except for SNPs rs9982601 (p = 0.009) and rs10947789 (p = 0.02). Hazard ratios are for incident CHD associations from this study; odds ratio are from published results from the publication from Deloukas, P., S. Kanoni, et al. (2013). "Large-scale association analysis identifies new risk loci for coronary artery disease." Nature Genetics. 45(1): 25–33.
Associations of validated CHD loci with incident coronary heart disease in African Americans.