Additional file 9 of Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease

Additional file 9: Table S1: Protein abundance and CVs of 3 fractions of pooled plasma. Table S2: Protein overlap across 3 fractions of pooled plasma. Table S3: Pooled plasma ANOVA. Table S4: Set 1 sample information (n = 36). Table S5: (Set 1 + Set 2) raw protein abundance (n = 121). Table S6: Set 1 variance-corrected protein abundance. Table S7: Set 1 Student's t-test (heparin enrichment). Table S8: Set 1 Student's t-test (top 14 removal). Table S9: Protein overlap between heparin enrichment and top 14 removal. Table S10: SomaScan median-centered data Table S11: Olink median-centered data. Table S12: Protein overlap across Heparin-MS, SomaScan and Olink. Table S13: SomaScan Student's t-test. Table S14: Olink Student's t-test. Table S15: Set 2 sample information (n = 85). Table S16: Set 2 variance-corrected protein abundance. Table S17: Plasma protein concentration. Table S18: Protein overlap between Set 1 and Set 2. Table S19: Set 2 Student's t-test. Table S20: (Set 1 + Set 2) sample information without outliers (n = 109). Table S21: (Set 1 + Set 2) meta-analysis of significance. Table S22: (Set 1 + Set 2) Z-transformed protein abundance. Table S23: Correlations between Z-score and AD biomarkers. Table S24: Correlations between SomaScan and AD biomarkers. Table S25: Correlations between Olink and AD biomarkers. Table S26: (Set 1 + Set 2) meta-analysis of significance after regression for age, sex, race and batch. Table S27: ROC curve statistics for highly significant plasma proteins and plasma pTau181 (n = 95, duplicated samples and missing values removed) .Table S28: (ROSMAP + BANNER) brain sample information (n = 456). Table S29: (ROSMAP + BANNER) variance-corrected protein abundance. Table S30: Protein overlap between FragPipe and Proteome Discoverer search of (ROSMAP + BANNER) brain dataset. Table S31: (ROSMAP + BANNER) ANOVA from FragPipe search. Table S32: (ROSMAP + BANNER) ANOVA from Proteome Discoverer search. Table S33: (ROSMAP + BANNER) module re-assignment. Table S34: Protein overlap between Hp-enriched plasma and brain datasets.