Crystal structure of mouse PI3 kinase delta in complex with GSK2269557
收藏Protein Data Bank Japan2024-06-19 更新2026-03-21 收录
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Crystal structure of mouse PI3 kinase delta in complex with GSK2269557 Descriptor: 6-(1H-Indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Authors: Down, K.D, Amour, A, Baldwin, I.R, Cooper, A.W.J, Deakin, A.M, Felton, L.M, Guntrip, S.B, Hardy, C, Harrison, Z.A, Jones, K.L, Jones, P, Keeling, S.E, Le, J, Livia, S, Lucas, F, Lunniss, C.J, Parr, N.J, Robinson, E, Rowland, P, Smith, S, Thomas, D.A, Vitulli, G, Washio, Y, Hamblin, N. Deposit date: 2015-08-26 Release date: 2015-09-16 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase Gamma for the Treatment of Respiratory Disease. J.Med.Chem., 58, 2015
创建时间：
2015-08-26
