A proteome dataset for TLR4 & IL1R activation & inhibition via FDA /EMA -approved drugs in chondrocytes, osteoblasts and synoviocytes

Mendely Data associated with:
Title: A transcriptome & proteome dataset for TLR4 & IL1R activation & inhibition in chondrocytes, osteoblasts and synoviocytes
Journal Title: Data in Brief
Corresponding Author: Dr. Rodolfo Gomez
All Authors: Eloi Franco-Trepat; María Guillán-Fresco; Ana Alonso-Pérez; Miriam López-Fagúndez; Andrés Pazos-Pérez; Antia Crespo-Golmar; Oreste Gualillo; Alberto Jorge-Mora; Susana Belén Bravo; Rodolfo Gomez
DOI: PENDING

The data provided is also associated as Supplementary Data to
Title: Repurposing drugs to inhibit innate immune responses associated with TLR4, IL1, and NLRP3 signaling in joint cells
Journal Title: Biomedicine & Pharmacotherapy
Corresponding Author: Dr. Rodolfo Gomez
All Authors: Eloi Franco-Trepat; María Guillán-Fresco; Ana Alonso-Pérez; Miriam López-Fagúndez; Andrés Pazos-Pérez; Antia Crespo-Golmar; Oreste Gualillo; Alberto Jorge-Mora; Susana Belén Bravo; Rodolfo Gomez
DOI: doi.org/10.1016/j.biopha.2022.113671

Data Description
Table 1
Merged dataset of approved drugs by the Federal Drugs Agency (FDA) & European Medicine Agency (EMA). Synonyms, formulations, and doses were included as individual entries.
Table 2
Merged dataset of approved active compounds by the Federal Drugs Agency (FDA) & European Medicine Agency (EMA). Synonyms, formulations, and doses were included as individual entries.
Table 3
List of all primers used in the manuscript including sequence, melting temperature and RefSeq. All primers were purchased as “KiCqStart® SYBR® Green Primers” ref. KSPQ12012 (Merck; USA).
Table 4
Cellular proteome & secretome qualitative DDA data (n3) obtained by MALDI-TOFF of primary human OA chondrocytes (Control, TLR4 agonist LPS [100ng/ml] and IL1R agonist IL1β [0.1ng/ml]).
Table 5
Cellular proteome quantitative SWATH data (n=3) obtained by MALDI-TOFF of primary human OA chondrocytes (Control, TLR4 agonist LPS [100ng/ml] and IL1R agonist IL1β [0.1ng/ml]).