miRNA expression profiles of exosomes from polarized bone marrow derived macrophages. miRNA expression profiles of exosomes from polarized bone marrow derived macrophages

Unprogrammed macrophage polarization, is associated with diabetic wound ulcers. Nevertheless, development of corresponding drugs is still a challenge. Here, exosomes are isolated from naive bone marrow-derived macrophages (BMDMs) (M0-Exos), inflammatory BMDMs (M1-Exos), and anti-inflammatory BMDMs (M2-Exos), with the aim of pinpointing the exosomes functionality and identify global miRNAs expression profiles. Overall design: Expression profile analysis of exosomal microRNA data from M1(pro-inflammatory macrophages), M2 (anti-inflammatory macrophages) and M0 (unpolarized macrophages).