Pan-Cancer Metabolism Data Explorer

Pan-Cancer Metabolism Data Explorer, is an informatic pipeline to concurrently analyze metabolomics data from over 900 tissue samples spanning seven cancer types, revealing extensive heterogeneity in metabolic changes relative to normal tissue across cancers of different tissues of origin. Despite this heterogeneity, a number of metabolites were recurrently differentially abundant across many cancers, such as lactate and acyl-carnitine species.泛癌代谢组数据探索器（Pan-Cancer Metabolism Data Explorer）是一款信息学分析流程，可同时分析覆盖7种癌症类型的900余份组织样本的代谢组学数据，能够揭示不同组织起源的癌症中与正常组织相比代谢改变存在的广泛异质性。尽管存在此类异质性，但仍有多种代谢物在多种癌症中反复出现丰度差异，例如乳酸盐及酰基肉碱类物质。

搜集汇总

背景与挑战

背景概述

Pan-Cancer Metabolism Data Explorer是一个信息学管道，用于同时分析覆盖七种癌症类型的900多个组织样本的代谢组学数据，揭示了不同起源组织癌症中代谢变化相对于正常组织的广泛异质性。尽管存在异质性，但多种代谢物如乳酸和酰基肉碱在众多癌症中反复出现差异丰度。