E. coli strain W3110 cultured in M9 minimal medium with 10 g/L glycerol was exposed to 5 mM p-CA at the exponential growth phase.

p-Coumaric acid is an aromatic secondary metabolite produced by plants. This compound is found in plant-derived food consumed by humans. p-Coumaric acid and derived compounds have positive effects on human health, so there is interest in producing them in biotechnological processes with recombinant Escherichia coli strains. To determine the physiologic response of E. coli W3110 to p-coumaric acid, transcriptome analysis was performed at 20 and 60 minutes after exposure to this compound.