Additional file 6 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Additional file 5 Gene lists and GO enrichment analyses for Pxr-/- vs Pxr+/+ transcriptome comparisons. (A) List of genes significantly up-regulated in males Pxr-/- compared to males Pxr+/+. (B) GO term enrichment analysis using the list of genes significantly up-regulated in males Pxr-/- compared to males Pxr+/+. Metabolic pathways (summary) were considered as significantly enriched when q-value < 0.05. (C) List of genes significantly up-regulated in females Pxr-/- compared to females Pxr+/+. (D) GO term enrichment analysis using the list of genes significantly up-regulated in females Pxr-/- compared to females Pxr+/+. Metabolic pathways (summary) were considered as significantly enriched when q-value < 0.05. (E) List of genes significantly down-regulated in males Pxr-/- compared to males Pxr+/+. (F) GO term enrichment analysis using the list of genes significantly up-regulated in males Pxr-/- compared to males Pxr+/+. No summary metabolic pathways (summary) were considered as significantly enriched with q-value < 0.05. (A) List of genes significantly down-regulated in females Pxr-/- compared to females Pxr+/+. (B) GO term enrichment analysis using the list of genes significantly down-regulated in females Pxr-/- compared to females Pxr+/+. Metabolic pathways (summary) were considered as significantly enriched when q-value < 0.05.

附加文件5：Pxr-/-与Pxr+/+转录组比较的基因列表及基因本体（GO，Gene Ontology）富集分析。
(A) 雄性Pxr-/-个体相较雄性Pxr+/+个体显著上调的基因列表。
(B) 针对雄性Pxr-/-相较雄性Pxr+/+显著上调基因列表开展的GO术语富集分析。当q值（q-value）<0.05时，汇总代谢通路被视为显著富集。
(C) 雌性Pxr-/-个体相较雌性Pxr+/+个体显著上调的基因列表。
(D) 针对雌性Pxr-/-相较雌性Pxr+/+显著上调基因列表开展的GO术语富集分析。当q值<0.05时，汇总代谢通路被视为显著富集。
(E) 雄性Pxr-/-个体相较雄性Pxr+/+个体显著下调的基因列表。
(F) 针对雄性Pxr-/-相较雄性Pxr+/+显著上调基因列表开展的GO术语富集分析。当q值<0.05时，未发现汇总代谢通路存在显著富集。
(A) 雌性Pxr-/-个体相较雌性Pxr+/+个体显著下调的基因列表。
(B) 针对雌性Pxr-/-相较雌性Pxr+/+显著下调基因列表开展的GO术语富集分析。当q值<0.05时，汇总代谢通路被视为显著富集。