Shifts in uterine microbiome associated with pregnancy outcomes at first insemination and clinical cure in dairy cows with metritis

The main hypothesis of the current study was that the uterine microbiome in dairy cows with metritis that become pregnant following the first AI postpartum differs from that of cows with metritis that fail to become pregnant. Moreover, we hypothesized that the microbiome of cows with metritis that become pregnant following the first AI postpartum is similar to that observed in cows without metritis independently of pregnancy outcomes. Finally, we hypothesized that clinical cure failure in dairy cows treated for metritis is associated with differences in the uterine microbiome. Therefore, the objectives were to characterize the uterine microbiome in dairy cows with and without metritis on the day of the diagnosis, five days later upon completion of antimicrobial therapy, and at 40 days postpartum.All raw data are available at Microbial Genomes NCBI (Bioproject# PRJNA983811)