Supporting electrophysiological data for: Reward contingency gates selective cholinergic suppression of amygdala neurons

Basal forebrain cholinergic neurons modulate how organisms process and respond to environmental stimuli through impacts on arousal, attention, and memory. It is unknown, however, whether basal forebrain cholinergic neurons are directly involved in conditioned behavior, independent of secondary roles in the processing of external stimuli. Using fluorescent imaging, we found that cholinergic neurons are active during behavioral responding for a reward – even in prior to reward delivery and in the absence of discrete stimuli. Photostimulation of basal forebrain cholinergic neurons, or their terminals in the basolateral amygdala (BLA), selectively promoted conditioned responding (licking), but not unconditioned behavior nor innate motor outputs. In vivo electrophysiological recordings during cholinergic photostimulation revealed reward-contingency-dependent suppression of BLA neural activity, but not prefrontal cortex (PFC). Finally, ex vivo experiments demonstrated that photostimulation of..., Please see methods section in the methods section of this paper:
Kimchi Eyal Y., Burgos-Robles Anthony, Matthews Gillian A., Chakoma Tatenda, Patarino Makenzie, Weddington Javier, Siciliano Cody A., Yang Wannan, Foutch Shaun, Simons Renee, Fong Ming-fai, Jing Miao, Li Yulong, Polley Daniel B., Tye Kay M. (2023) Reward contingency gates selective cholinergic suppression of amygdala neurons eLife 12:RP89093
https://doi.org/10.7554/eLife.89093.1, , # Ephys data for \"Reward contingency gates selective cholinergic suppression of amygdala neurons\"

[https://doi.org/10.5061/dryad.dbrv15f85](https://doi.org/10.5061/dryad.dbrv15f85)

This dataset contains individual .NWB files containing all raw in vivo electrophysiological data for this project and one MATLAB (.MAT) file. 

Neurodata Without Borders (NWB) is a data standard for neurophysiology, providing neuroscientists with a common standard to share, archive, use, and build common analysis tools for neurophysiology data. NWB is designed to store a variety of neurophysiology data, including data from intracellular and extracellular electrophysiology experiments, data from optical physiology experiments, and tracking and stimulus data. Neurodata Without Borders is intended to serve the broad neuroscience community and encourage the sharing of data by scientists worldwide. NWB 2.0 ([https://www.nwb.org/2019/02/26/nwbn-2-0-final-released/](https://www.nwb.org/2019/02/26/nwbn-2-0-final-re...