Fibrinogen as a potential diagnostic marker for prediction and evaluation of postpartum hemorrhage: a retrospective study

To investigate whether prenatal fibrinogen (FIB) or other related factors could be utilized to evaluate the risk of postpartum hemorrhage (PPH). A retrospective study was conducted in a database from January 2015 to December 2019. A total of 128 patients were enrolled and evaluated with FIB, in which 55 patients were assigned to low FIB and 73 in normal FIB. According to the volume of blood loss, the mean of the low FIB group (&lt;4 g/L) was markedly higher than that of the normal FIB group (≥4 g/L). Prenatal FIB was negatively correlated with PPH volume. The receiver operating characteristic (ROC) curve results indicated that the value of prenatal FIB was 0.701 to predict refractory PPH. Prenatal FIB was significantly related to thrombin time (TT), which may be an independent factor to predict the coagulation state of prenatal pregnancy.为探讨产前纤维蛋白原（fibrinogen, FIB）及其他相关因素能否用于评估产后出血（postpartum hemorrhage, PPH）的发病风险，本研究基于2015年1月至2019年12月的数据库开展了一项回顾性研究。共纳入128例患者并检测其产前FIB水平，其中55例被分配至低FIB组（<4 g/L），73例归入正常FIB组（≥4 g/L）。按失血量统计，低FIB组的平均失血量显著高于正常FIB组。产前FIB水平与产后失血量呈负相关。受试者工作特征（receiver operating characteristic, ROC）曲线分析结果显示，产前FIB预测难治性产后出血（refractory PPH）的曲线下面积为0.701。产前FIB水平与凝血酶时间（thrombin time, TT）显著相关，其或可作为预测产前妊娠凝血状态的独立预测因子。