Additional file 1 of Diagnostic accuracy of pooling urine, anorectal, and oropharyngeal specimens for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae: a systematic review and meta-analysis

Additional file 1: Appendix 1. Search strategy. Appendix 2. Further details of multisite pooled sampling for chlamydia and gonorrhoea. Supplementary Figure 1. Receiver operating characteristic (ROC) curve for multisite pooled testing for chlamydia. Supplementary Figure 2. Assessment for small study effects for multisite pooled testing for chlamydia. Supplementary Figure 3. Risk of bias summary as percentage. Supplementary Figure 4. Receiver operating characteristic (ROC) curve for multisite pooled testing for gonorrhoea. Supplementary Figure 5. Assessment for small study effects for multisite pooled testing for gonorrhoea. Supplementary Table 1. Meta-regression of the accuracy of multisite pooled testing for chlamydia according to study characteristics. Supplementary Table 2. The positive predictive value (PPV) and negative predictive value (NPV) for multisite pooled testing for chlamydia, over a range of background prevalence of chlamydia. Supplementary Table 3. Risk of Bias summary. Supplementary Table 4. GRADE table for multisite pooled testing for chlamydia. Supplementary Table 5. Meta-regression of the accuracy of multisite pooled testing for gonorrhoea according to study characteristics. Supplementary Table 6. The positive predictive value (PPV) and negative predictive value (NPV) for multisite pooled testing for gonorrhoea, over a range of background prevalence of gonorrhoea. Supplementary Table 7. GRADE table for multisite pooled testing for gonorrhoea. Supplementary Table 8. Study characteristics, methods of pooling, reported sensitivity and specificity of multisite pooled testing. References.

附加文件1：附录1：检索策略。
附录2：沙眼衣原体与淋病多中心合并采样的进一步细节。
补充图1：沙眼衣原体多中心合并检测的受试者工作特征（Receiver Operating Characteristic, ROC）曲线。
补充图2：沙眼衣原体多中心合并检测的小样本研究效应评估。
补充图3：以百分比形式呈现的偏倚风险汇总。
补充图4：淋病多中心合并检测的受试者工作特征（Receiver Operating Characteristic, ROC）曲线。
补充图5：淋病多中心合并检测的小样本研究效应评估。
补充表1：基于研究特征的沙眼衣原体多中心合并检测准确度的Meta回归分析。
补充表2：不同沙眼衣原体背景患病率下，沙眼衣原体多中心合并检测的阳性预测值（Positive Predictive Value, PPV）与阴性预测值（Negative Predictive Value, NPV）。
补充表3：偏倚风险汇总表。
补充表4：沙眼衣原体多中心合并检测的GRADE证据概要表。
补充表5：基于研究特征的淋病多中心合并检测准确度的Meta回归分析。
补充表6：不同淋病背景患病率下，淋病多中心合并检测的阳性预测值（Positive Predictive Value, PPV）与阴性预测值（Negative Predictive Value, NPV）。
补充表7：淋病多中心合并检测的GRADE证据概要表。
补充表8：多中心合并检测的研究特征、合并方法、报告的灵敏度与特异度。
参考文献。