Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model

we assessed characteristic molecular and proteomic signatures in rat liver treated with drugs (pyrazinamide, ranitidine, enalapril, carbamazepine, and chlorpromazine) that are known to cause DILI in humans.本研究评估了经已知可引发人类药物性肝损伤（Drug-Induced Liver Injury，DILI）的药物（吡嗪酰胺（pyrazinamide）、雷尼替丁（ranitidine）、依那普利（enalapril）、卡马西平（carbamazepine）、氯丙嗪（chlorpromazine））处理的大鼠肝脏中的特征性分子与蛋白质组学特征（proteomic signatures）。