SUMOylation affects many aspects of target proteins such as activity, stability, localization and protein-protein interactions. We have found that SUMOylation of YTHDF2 increased its binding activity

NIAID Data Ecosystem60

A unified model for the function of YTHDF proteins in the regulation of m6A-modified mRNA

m6A甲基化调控

YTHDF蛋白功能

N6-methyladenosine (m6A) is the most abundant mRNA nucleotide modification and regulates critical aspects of cellular physiology and differentiation. m6A is thought to mediate its effects through a co

NIAID Data Ecosystem30

Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation [RNA-seq]

m6A甲基化调控

巨噬细胞免疫

The involvement of m6A modification in macrophage activation has been validated in our study that the expression of TNF-a in Mettl3-depleted Raw 264.7 cells stimulated with LPS were markedly reduced i

NIAID Data Ecosystem70

Ythdf2 Suppresses the 2C-like State in Mouse Embryonic Stem Cells via Cooperation with Cnot1 [RNA-seq]. Ythdf2 Suppresses the 2C-like State in Mouse Embryonic Stem Cells via Cooperation with Cnot1 [RNA-seq]

胚胎干细胞转录组

m6A甲基化调控

Mouse embryonic stem cells (ESCs) consist of a rare population of heterogeneous cells which express 2-cell-stage-specific transcripts and are referred to as 2-cell-like cells (2CLCs). Accumulating evi

NIAID Data Ecosystem30

mRNA sequencing and methylated RNA immunoprecipitation sequencing in ALKBH5-overexpressing AC16 human cardiomyocytes

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