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Dynamic re-wiring of apoptotic signaling networks enhances tumor cell killing by DNA damage

ChEBI2012-05-14 更新2026-07-21 收录

细胞凋亡信号网络

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数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-30516 数据链接链接失效反馈

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资源简介：

Dynamic re-wiring of apoptotic signaling networks enhances tumor cell killing by DNA damage

应用场景：

创建时间：

2012-05-14

肿瘤靶向治疗

药物耐药机制

Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c

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Uncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation

PARP抑制剂机制

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PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytoto

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Regulation of gene expressions in vivo by anti-VEGF and anti-Notch therapy [HG-U133_Plus_2]

肿瘤靶向治疗

基因表达谱分析

U87-EV human glioblastoma xenograft tumours is therapeutically treated by bevacizumab, a humanized anti-human VEGF mAb, or dibenzazepine (DBZ), when tumour is established in BALB/c SCID mice. At the e

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肿瘤靶分子临床研究信息数据集

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临床研究

聚焦肿瘤靶分子临床研究全流程，整合靶点发现、临床试验设计、疗效数据、安全性评估等核心信息。数据经标准化清洗与专业校验，关联靶点分子结构、作用机制及临床结果，支持科研机构靶点验证、药企药物研发、临床机构方案优化，为靶分子临床转化提供高质量、可溯源的数据支撑。

江苏数据交易所80

Original images underlying Fig 3D.

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RNA干扰

Expression of Concern: Specific Inhibition of Tumor Cells by Oncogenic EGFR Specific Silencing by RNA interference

Figshare2024-12-13 更新50