KLRC1:KLRD1 heterodimer interacts with HLA-E

After interaction with its ligand HLA-E, which is expressed on normal cells, the C-type lectin inhibitory receptor CD94/NKG2A suppresses activation signaling processes. CD94/NKG2A receptors continuously recycle from the cell surface through endosomal compartments and back again in a process that requires energy and the cytoskeleton. This steady state process appears to be largely unaffected by exposure to ligand.

在与其配体HLA-E的相互作用后，HLA-E表达于正常细胞表面，C型凝集素抑制性受体CD94/NKG2A抑制了激活信号传导过程。CD94/NKG2A受体通过内体腔室在细胞表面与细胞内之间持续循环，这一过程需要能量和细胞骨架的参与。这一稳态过程似乎在很大程度上不受配体暴露的影响。