PREPRATON AND CHARACTERIZATION OF STEROID-LINKED DERIVATIVES AS ANTICANCER AGENTS"

of a variety of regulatory function such as ovulation, development of corpusluteum, and maintenance of
uterine quiescence during pregnancy. It is also involved in proliferation and differentiation of mammary
glands. The biological activity of progesterone is mediated by the progesterone receptor [PR], a member
of the large gene family of nuclear receptors, which induces a cascade of transcriptional events after
binding with the hormone. PR contains three functional domains including the N-terminus, a centrally
located DNA binding domain (DBD) and C-terminal ligand binging domain (LBD) respectively. The
binding of progesterone induces of conformational change in PR that promotes dissociation from a
multi-protein complex followed by homo dimerization and binding to specific progesterone response
elements (PRE) within the promoter genes. The hormone activated PR recruits co-activators throug