Dynamics of Furanosides: Inelastic Neutron Scattering Spectra of Methyl alpha- and beta-D-Ribofuranosides

Ribofuranoside is a five member ring sugar which plays important biochemical function. As opposed to the six-membered ring, in which bond lengths, bond angles, and dihedral angles can be maintained at their minimum energy values in a well defined and strain free chair conformation, the five-membered ring is strained in all conformations. Numerous conformational preferences of ribofuranoside, including ring-puckering, dynamics of hydroxyl and hydroxymethyl groups, intermolecular hydrogen bonding and internal rotation of the methyl group offer a plethora of possible interactions that may guide their biological function. Here we present a case for study of representative furanoside, namely methyl alpha- and beta-D-ribofuranosides.呋喃核糖苷（Ribofuranoside）是一类五元环糖类，发挥着重要的生化功能。与六元环糖类不同，后者可通过构象明确且无张力的椅式构象，将键长、键角与二面角维持在最低能量水平；而五元环在所有构象中均存在结构张力。呋喃核糖苷存在诸多构象偏好，涵盖环折叠行为、羟基与羟甲基基团的动态特性、分子间氢键作用以及甲基的内旋转运动，这些相互作用形式丰富，或可指导其生物学功能的实现。本研究选取代表性呋喃糖苷，即甲基α-D-呋喃核糖苷与甲基β-D-呋喃核糖苷作为研究对象。