IL-4 Receptor a Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo through the Enhancement of Intestinal Mucosal Barrier Function
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE157754
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资源简介：
In the present study we investigate the role of IL-4 receptor a subunit in intestinal inflammation using DSS-induced colitis model. Our finding suggest that IL-4Ra deficiency enhances intestinal mucosal barrier function through the upregulation of NOX1-dependent ROS production, thereby suppressing the development of intestinal inflammation. Gene expression profile in the colon tissue of WT and IL-4Ra-/- treated with 3% DSS or water as a control for 7 days. Mice colon were analyzed on day 7 after DSS treatment. mRNA samples was pooled from 3-6 mice of each group (WT Normal, WT Colitis and KO Colitis)
创建时间：
2020-12-10
