Transcriptomic changes of sigmoidal gut biopsies in psoriasis patients and healthy subjects

This study aims to understand the systemic component of psoriasis pathogenesis since psoriasis patients have higher risk of developing diesases beyond skin inflammation. In this study, we collected sigmoidal gut biopsies to profile host transcriptomic changes associated with psoriasis patients and healthy subjects. This exepriment provided transcriptomic dataset of host response and is integrated with fecal metagenomic data and flow cytometry dataset as part of the multi-omic study. Total RNA isolated from snip biopsies of sigmoidal colon and used for whold transcriptome RNAseq. The RNAseq analysis was done with 16 healthy subjects and 26 psoriasis patients.