The RFX transcription factor gene, daf-19, has dual funcitons in ciliated and non-ciliated neurons

Cilia are required for many sensory and motility related functions and are involved in growing number of genetic disorders termed ciliopathies. DAF-19, RFX type transcription factor controls expression of many cilia structure and function related genes. To this end, transcriptional profiling of daf-19 mutants (which do not form cilia) and wild-type animals was performed using selectively staged larval stages where cilia mature and maintained, structurally as well as functionally.纤毛（Cilia）介导诸多感知与运动相关的生理功能，并与日益增多的被命名为纤毛病（ciliopathies）的遗传疾病紧密相关。DAF-19作为RFX型转录因子，可调控大量与纤毛结构及功能相关基因的表达。为此，研究人员选取纤毛在结构与功能层面均完成成熟与维持的选择性分期幼虫阶段，对无法形成纤毛的daf-19突变体与野生型动物开展了转录谱分析（transcriptional profiling）。