One-Pot Amberlyst 15-Controlled Cyclocondensation of Piperidines and Arylaldehydes: Synthesis of 3,5-Diarylmethylpyridines

Amberlyst 15-controlled one-pot easy-operational
intermolecular
cyclocondensation of substituted piperidines with arylaldehydes provides
diversified 3,5-diarylmethylpyridines in high to excellent yields
under refluxing toluene conditions. The uses of various acidic solid
supports and reaction solvents are investigated for facile and efficient
transformation. A plausible mechanism has been proposed.