METHODS FOR ENGINEERING T CELLS FOR IMMUNOTHERAPY BY USING RNA-GUIDED CAS NUCLEASE SYSTEM
收藏国家林业和草原科学数据中心2023-02-12 更新2024-03-07 收录
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资源简介：
The present invention relates to methods of developing genetically engineered， preferably non-alloreactive T-cells for immunotherapy. This method involves the use of RNA-guided endonucleases， in particular Cas9/CRISPR system， to specifically target a selection of key genes in T-cells. The engineered T-cells are also intended to express chimeric antigen receptors (CAR) to redirect their immune activity towards malignant or infected cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies using T-Cells for treating cancer and viral infections.
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国家林业和草原科学数据中心
创建时间：
2023-02-12
