GPR124 Protects against Podocyte Senescence and Injury in Diabetic Kidney Disease

Cellular senescence is associated with the progression of diabetic kidney disease (DKD), and accelerated podocyte senescence promotes the pathogenesis of renal damage. We found that GPR124 was reduced in cultured human podocytes treated with high glucose (HG).To further clarify the role of GPR124 in podocytes, we overexpressed GPR124 via plasmid-harboring adenovirus infection. By RNA sequencing analysis of podocytes with different treatment, we observed GPR124 overexpression significantly affected several kinds of cell adhesion. Pairwise comparison of gene expression in 4 different groups of podocytes (3 samples per group) was performed by RNA sequencing, including NC control, NC HG, OE control and OE HG.