Progression to AML is predictable and distinct from age related clonal hematopoiesis
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https://www.omicsdi.org/dataset/ega/EGAS00001002570
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To examine the occurrence of somatic mutations prior to the development of acute myeloid leukemia, we undertook deep ECS (estimated limit of detection 1 mutation in 2500 cells) of 261 AML associated genes in 96 pre-AML cases and 420 age and gender-matched healthy controls of an average of 3853 unique DNA molecules covering each of the 1.19M bases spanning the target gene panel. The findings suggest that the development of clonal hematopoiesis and accumulation of somatic mutations is distinct and accelerated in pre-AML cases compared to healthy individualsEGA study EGAS00001002570
创建时间：
2021-10-19
