Arginine methylation of histone and non-histone proteins is involved in transcription regulation and many other cellular processes. Nevertheless, whether such protein modification plays a regulatory r

NIAID Data Ecosystem90

Regulation of the circadian clock by the metabolic enzyme AHCY

昼夜节律调控

表观遗传修饰

Mammalian circadian rhythms are based on coupled transcriptional-translational feedback loops driven by the transcription factors CLOCK and BMAL1. Chromatin remodeling mechanisms are essential for the

NIAID Data Ecosystem70

O-GlcNAc Aminidase is an RNA Pol II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1b

转录调控

表观遗传修饰

ChIP-seq shows that OGA and O-GlcNAc are found at promoters/TSS concomitantly with the known elongation factors SPT5 and TIF1b as well as RNA pol II. There are gene body overlaps of various combinati

NIAID Data Ecosystem100

LncPRESS1 is a p53-regulated lncRNA that safeguards pluripotency by disrupting SIRT6 mediated de-acetylation of histone H3K56

干细胞多能性调控

表观遗传修饰

Recent evidence suggests that lncRNAs play an integral regulatory role in numerous functions, including determination of cellular identity. We determined global expression (RNA-seq) and genome wide pr

NIAID Data Ecosystem70

Cyprinus carpio Epigenomics

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