Table_2_Association Between Childhood Maltreatment and Symptoms of Obsessive-Compulsive Disorder: A Meta-Analysis.XLSX

Background: Previous studies have indicated that childhood maltreatment (CM) may potentially influence the clinical symptomatology of obsessive-compulsive disorder (OCD). Here, we aimed to quantify the relationship between CM and obsessive-compulsive symptoms (OCS) and depressive symptoms in OCD through a meta-analysis.Method: We searched PubMed, Embase, Cochrane Library, and PsycARTICLES databases for articles reporting the association between CM and OCD on April 15, 2020. Random-effect models were used to quantify the relationship between CM and the severity of OCS and depressive symptoms in OCD.Results: Ten records with 1,611 OCD patients were included in the meta-analysis. The results revealed that CM is positively correlated with the severity of OCS [r = 0.10, 95%Confidence Interval (CI): 0.01–0.19, P = 0.04] as well as depressive symptoms in OCD (r = 0.15, 95%CI: 0.07–0.24, P = 0.0002). For the subtypes of CM, childhood emotional abuse (CEA) and childhood sexual abuse (CSA) was related with the severity of OCS (r = 0.11, 95%CI: 0.03–0.19, P = 0.009) and obsession (r = 0.13, 95%CI: 0.03–0.23, P = 0.01), respectively.Conclusion: Our meta-analysis indicates that OCD patients who suffered more CM may exhibit more severe OCS and depressive symptoms.

背景：既往研究表明，儿童期虐待（CM）可能对强迫症（OCD）的临床症状谱产生影响。本研究旨在通过荟萃分析量化CM与OCD中强迫症状（OCS）及抑郁症状之间的关系。方法：我们于2020年4月15日检索了PubMed、Embase、Cochrane图书馆和PsycARTICLES数据库中关于CM与OCD关联的文章。采用随机效应模型对CM与OCS严重程度及抑郁症状之间的关系进行量化分析。结果：荟萃分析纳入了10篇记录，涉及1,611名OCD患者。结果显示，CM与OCS严重程度呈正相关[r = 0.10，95%置信区间（CI）：0.01–0.19，P = 0.04]以及OCD中的抑郁症状（r = 0.15，95%CI：0.07–0.24，P = 0.0002）。对于CM的亚型，儿童期情感虐待（CEA）和儿童期性虐待（CSA）分别与OCS严重程度（r = 0.11，95%CI：0.03–0.19，P = 0.009）及强迫行为（r = 0.13，95%CI：0.03–0.23，P = 0.01）相关。结论：我们的荟萃分析表明，经历更多CM的OCD患者可能表现出更严重的OCS和抑郁症状。