Rubric on scoring the CHANT tool.

These combinations of values represent all possibilities of CHANT+ve neuropathy test results. The four-item CHANT was tested in silico within the stringent HIV-PINS diagnostic criteria so as to assess its accuracy performance for diagnosing neuropathy; this testing showed a high sensitivity and specificity of 82% and 90% respectively, while employing a minimum of ‘bilateral feet pain/reduced great toe vibration’ AND ‘bilateral feet numbness/reduced ankle reflex’ (Fig 4). Hence, this cutoff was selected to diagnose HIV-PN when applying CHANT.