Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (BPA). Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (BPA)

Pregannt Cyp19-EGFP mice (maintained on a soybean free mouse chow diet) were treated with either 50μg/kg/day Bsiphenol A or vehicle (ethinol in peanut oil) between gestational days (GD) 10.5-14.5. On GD15.5, fetuses were dissected and sex determined by SRY genotyping. Fetuses were obtained from different dams. Overall design: To investigate the effect of prenatal BPA expsoure on offspring RNA expression, Cyp19-EGFP mice dams were treated with either 50μg/kg BPA or vehicle (peanut oil) at GD10.5-GD14.5. The cortex of the brain was rapidly dissected from the fetuses at GD15.5.