Inhibition of pyrimidine biosynthesis targets protein translation in AML [RNA-seq_MN]
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https://www.ncbi.nlm.nih.gov/sra/SRP331539
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资源简介：
Investigation of the transcriptional profile of MLL-rearranged AML in response to DHODH inhibition by AG636. Chemo-refractory syngeneic murine AML model driven by doxycycline-inducible expression of MLL-AF9 and constitutive expression of oncogenic Nras (MN) was transplanted into Ptprca recipients. Mice bearing MN tumors were treated with doxycycline or AG636 for one or four days. Leukemic stem cells (cKit high; CD11b low) from bone marrow and spleen were isolated and RNA sequencing performed. Overall design: Gene expression profiles of Vehicle-, AG636- or Doxycycline-treated MN AML cells.
创建时间：
2022-07-21
