Effects of siRNA knock-down on the number, duration and relative power of HVSs, and the HVS-related coherence of the M1–GP pair.

A: number of HVSs. B: duration of HVSs. C: representative averaged relative power spectral density curve of the M1 cortex (ECoG) and of the GP LFP recorded from the rats injected with: AAV-shSCR (black lines), AAV-shRNA-D1 (red lines) and AAV-shRNA-D2 (blue lines). D: relative power of both the M1 cortex and GP LFP in the frequency bands associated with HVS oscillations. E: averaged coherence curves of the M1–GP pair in the rats injected with: AAV-shSCR (black lines), AAV-shRNA-D1 (red lines) and AAV-shRNA-D2 (blue lines). F: coherence values relating to the HVSs. HVSs, high-voltage spindles; M1, primary motor cortex; GP, globus pallidus. *P#Significant difference between AAV-shRNA-D1 and AAV-shRNA-D2.