Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

ChEBI2014-09-19 更新2026-07-21 收录

黑色素瘤耐药性

靶向治疗生物标志物

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Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

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2014-09-19

Gene expression profiling of oncogenic NRAS driven mouse melanomas that have developed resistance to NRAS withdrawal. Mus musculus

黑色素瘤耐药性

RAS突变肿瘤

Targeted therapies have the potential to revolutionize cancer care by providing personalized treatment strategies that are less toxic and more effective but it is clear that for most solid tumors supp

NIAID Data Ecosystem70

Acetylcytidine modification of DDX41 and ZNF746 by N-acetyltransferase 10 contributes to chemoresistance of melanoma

黑色素瘤耐药性

RNA修饰机制

We performed RNA-seq to analyse the different expression genes of DTIC-resistant (DR) A375 cells and wild-type control. Examination of differentially expressed genes in DR A375 cells compared with wil

NIAID Data Ecosystem50

Homo sapiens strain:A375 BRAFV600E melanoma clones with acquired resistance to vemurafenib Exome

黑色素瘤耐药性

外显子组测序数据分析

Nimblegen exome capture was performed and was followed by Illumina DNA library preparation and sequencing on the Illumina GAIIx platform. Sequence data was then used to help characterize the BRAF cod

NIAID Data Ecosystem30

Proteomics identifies markers of MAPKi resistance offering new therapeutic strategies in melanoma- Cytoplasmic (cyt), nuclear (ne) and secreted (sn) proteins of MAPKi sensitive melanoma cells

黑色素瘤耐药性

蛋白质组学生物标志物

MAPK inhibitors (MAPKi) show outstanding clinical response rates in melanoma patients harbouring BRAF mutations, but resistance is common. High-throughput, subcellular proteome analyses at two differe

NIAID Data Ecosystem60

Fusion detection in cancer (n = 613).

癌症基因组数据

靶向治疗生物标志物

Kinase-related gene fusion and point mutations play pivotal roles as drivers in cancer, necessitating optimized, targeted therapy against these alterations. The efficacy of molecularly targeted therap

NIAID Data Ecosystem30

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

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