Supplemental data for the manuscript "Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy"

Name: Supplemental data for the manuscript "Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy"
Creator: Nakashima, Hiroyuki; Nakashima, Masahiro; Oshima, Naoki; Kinoshita, Manabu; Yamagata, Akira; Seki, Shuhji; Kumagai, Hiroo; Ishikiriyama, Takuya; Imakiire, Toshihiko; Ito, Seigo
Published: 2021-11-10 00:00:00
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Figshare2021-11-10 更新2026-04-08 收录

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https://figshare.com/articles/dataset/Supplemental_data_for_the_manuscript_Effects_of_a_CCR2_antagonist_on_macrophages_and_Toll-like_receptor_9_expression_in_a_mouse_model_of_diabetic_nephropathy_/16607996/3

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We classified kidney macrophages (Mφs) into bone marrow-derived (BM-) macrophages expressing high CD11b and tissue-specific resident (Res-) macrophages expressing low CD11b. In diabetic nephropathy (DN) model mice, TLR9 expression and TNF-α production via TLR9 activation in BM-Mφs and ROS production in Res-Mφs were enhanced. Furthermore, CCR2 antagonist suppressed the kidney infiltration of BM-Mφs and their function and the ROS production by Res-Mφs, with concomitant TLR9 suppression. Our study presents a new therapeutic strategy for DN.

提供机构：

Nakashima, Hiroyuki; Nakashima, Masahiro; Oshima, Naoki; Kinoshita, Manabu; Yamagata, Akira; Seki, Shuhji; Kumagai, Hiroo; Ishikiriyama, Takuya; Imakiire, Toshihiko; Ito, Seigo

创建时间：

2021-11-10