This is a Phase 1/2, first-in-human, open-label, dose escalation and dose-expansion study of E-602, administered alone and in combination with cemiplimab.

NIAID Data Ecosystem10

A microRNA-regulated transcriptional state defines intratumoral CD8+T cells that respond to immunotherapy. A microRNA-regulated transcriptional state defines intratumoral CD8+T cells that respond to immunotherapy

肿瘤免疫治疗

CD8T细胞转录状态

Rising rates of advanced-stage colorectal cancer (CRC) and poor survival rates necessitate effective therapeutic options. Immune checkpoint inhibition (ICI), specifically anti-PD-1 therapy, shows pote

NIAID Data Ecosystem00

Fig_5C_GFP-LPS-Smad1.tif

TGF-β信号通路

免疫反应分子机制

Total Smad1 expression levels in GFP+LPS group

DataCite Commons2025-07-10 更新30

DataSheet4_A systematic pan-cancer analysis reveals the clinical prognosis and immunotherapy value of C-X3-C motif ligand 1 (CX3CL1).ZIP

癌症生物标志物

肿瘤免疫治疗

It is now widely known that C-X3-C motif ligand 1 (CX3CL1) plays an essential part in the process of regulating pro-inflammatory cells migration across a wide range of inflammatory disorders, includin

NIAID Data Ecosystem00