Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid,
RNAseq samples from fSmoM2;hGFAPcre spontaneous medulloblastoma and treated with vehicle or LDE225. RNAseq samples from Ptch;p53 SI-CSC or SD-CSV tumors treated with vehicle or LDE225
We have previously isolated a murine erythroleukemia cell line refractive to re-enter a cell differentiation program as opposite to the progenitor cell line. We use RNA-seq to identify differentially
