The pathogenesis of eosinophilic asthma: A positive feedback mechanism that promotes Th2 immune response via FLG deficiency

Eosinophilic asthma is a common subtype of asthma and often progresses to severe disease. In order to understand its pathogenesis, targeted next generation gene sequencing was performed on 77 Chinese EA patients and 431 Chinese healthy controls to obtain differential genomic variations. Among the 41 Single Nucleotide Polymorphisms screened for mutation sites greater than 3 patients, FLG rs192116923 and FLG rs75235053 were newly found to be associated with EA patients with AD and severe EA, respectively.