Data and results "Menopausal status is associated with a high risk for residual disease after cervical conization with positive margins"

A cross-sectional
study was conducted. The eligible patients were women who underwent
hysterectomy as a treatment option after having a positive endocervical margin
for CIN 2/3 in cervix conization specimens from 2000 to 2015. The patients were
divided into two groups based on the persistence of CIN 2/3 and absence of CIN
2/3 in hysterectomy specimens. Demographic, clinical and histology information
were collected in both groups. A total of 80 patients were eligible for the
study; 37 (46.3%) had no persistence of CIN 2/3 and 43 (53.7%) had persistence
of CIN 2/3 in the hysterectomy specimens. Demographic, clinical, and cone
specimen characteristics, and a visible squamocolumnar junction and type of
conization were analyzed as possible risk factors for the presence of residual
lesions at hysterectomy, and none of these variables were associated with
residual disease. Menopausal status was strongly associated with a high risk of
persistent residual disease 81.2% (OR 4.9, CI 1.27-18.9), P=0.014. In
the multivariate analysis, only a menopausal status (P=0.04) was
associated with a high risk of persistent lesions.