Transcription-dependent domain-scale 3D genome organization in dinoflagellates
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE153950
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资源简介：
Dinoflagellate chromosomes represent a unique evolutionary experiment, as they exist in a permanently condensed, liquid crystalline state, are not packaged by histones, and contain genes organized into polycistronic arrays, with minimal transcriptional regulation. We analyze the 3D genome of {Breviolum minutum}, and find large topological domains without chromatin loops, demarcated by convergent gene array boundaries (``dinoTADs’’). Transcriptional inhibition degrades dinoTADs, implicating transcription-induced supercoiling as the primary topological force in dinoflagellates. Hi-C libraries associated with the project
创建时间：
2021-06-03
