Supplementary Material for: Monitoring Mobility at Home: The GAIT-HUB Sensor-Based Protocol for Remote Gait Analysis

Introduction
Gait is a critical indicator of neurological health, with changes often signaling underlying decline. We developed a remote gait monitoring protocol using off-the-shelf shoe-based sensors (RunScribe) to assess gait parameters in real-world, home settings. This protocol, known as Gait Assessment with Innovative Technologies – Home-based Use and Benefit (GAIT-HUB), was tested in individuals with multiple sclerosis (MS), a population at high risk for gait impairment due to the disease’s variable progression.

Methods
Participants with MS completed an in-clinic baseline gait assessment using a validated sensor (G-Sensor®) and three weekly, remotely supervised gait assessments at home using the RunScribe sensors. Gait parameters were compared across devices using intra-class correlation coefficients (ICCs) and Bland-Altman analyses. Longitudinal reliability of remote assessments and system usability score (SUS) were evaluated.

Results
Twenty-nine participants (76% women, ages 19–67, PDDS range 0–5) successfully completed the home-based assessments. High agreement between devices was observed for gait speed, stride length, and cadence (ICCs > 0.90), though phases like stance and swing showed more variability. Bland-Altman analyses indicated minimal bias in most parameters. Longitudinal assessments demonstrated strong reliability (ICCs > 0.87) for key metrics, and SUS indicated good to excellent usability of the remote protocol.

Conclusion
The GAIT-HUB protocol enables reliable and feasible home-based gait monitoring using wearable sensors that patients can easily self-apply. This approach provides valuable insights into daily mobility patterns beyond clinical visits, supporting more precise and timely assessments of functional status between appointments and offering the potential for seamless integration into telemedicine routine care.