A quantification of S. aureus AT skews.

AT skew values in coding positions in this table are given with respect to the protein-coding sense direction of a gene and are differentiated into whether they lie on the leading or lagging strand (see Figure 1). While ex-operonic skews are calculated from all available ex-operonic sequence, intra-operonic skews are calculated only for the strand on which the surrounding genes are transcribed. P was calculated as (r+1)/(n+1), where r is the number of simulated genomes resulting in a difference in AT skew values between the leading and lagging strands equal to or greater in magnitude than that observed in the reference (TW20) genome, and n is the total number of simulations performed (10,000).