Creb1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cAMP response element binding activity. Involved in several processes, including cellular response to retinoic acid; protein stabilization; and regulation of lipid biosynthetic process. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; lung development; and nervous system development. Located in chromatin and nucleus. Part of ATF4-CREB1 transcription factor complex. Is expressed in several structures, including brain; genitourinary system; limb; lung; and maxillary process. Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human CREB1 (cAMP responsive element binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]

激活DNA结合转录激活剂活性，特异性作用于RNA聚合酶II及cAMP反应元件结合活性。参与多项生理过程，包括细胞对维甲酸的响应；蛋白质稳定化；及脂质生物合成过程的调控。在细胞对肝细胞生长因子刺激的响应、肺发育以及神经系统发育等过程中发挥上游或内部作用。定位于染色质和细胞核内。构成ATF4-CREB1转录因子复合体的一部分。在包括大脑、生殖泌尿系统、肢体、肺以及上颌骨发育等结构中表达。该基因的人类同源基因与帕金森病、酒精依赖及海洛因依赖相关。与人类CREB1（cAMP反应元件结合蛋白1）同源。[由基因组资源联盟提供，2024年11月]