miR-22 microRNA binds PTEN mRNA

MicroRNA miR-22-3p, one of the two mature products of miR-22, binds the 3'UTR of PTEN mRNA (Poliseno et al. 2010). miR-22 causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-22 also functions as a part of the nonendonucleolytic RISC.

MicroRNA miR-22-3p，作为miR-22的两个成熟产物之一，与PTEN mRNA（3'非翻译区）结合（Poliseno等人，2010年）。miR-22导致PTEN mRNA及蛋白水平降低，从而证实其在内切核酸酶活性RISC（RNA诱导的沉默复合体）中的作用。此外，miR-22可能亦作为非内切核酸酶活性RISC的组成部分发挥作用。